Description

JWH-007 For Sale

What is JWH-007?

JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. Buy JWH-007 Online.

Product Description, Buy JWH-007 Online

Chemical Name	JWH 007
Synonyms	(2-Methyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone-d9
CAS Number	1651833-48-5
Molecular Formula	C₂₅H₁₆D₉NO
Molecular Weight	364.53
Category	So, Standards; Pharmaceutical/API Drug Impurities/Metabolites;
So,Applications	Most importantly,Labelled version of JWH-007 (J211340) is a novel cannabinoid receptor agonist at both the CB1 and CB2 receptors. Synthetic Cannabinoids

 

Above all it is most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman

Nevertheless several years after the family was initially described with the discovery of the N-morpholinylethyl compounds pravadoline (WIN 48,098), JWH-200 (WIN 55,225) and so WIN 55,212-2 by the Sterling Winthrop group.

In other words several other N-alkyl substituents were found to be active by Huffman’s team including the n-butyl, n-hexyl, 2-heptyl, and also cyclohexylethyl groups,

Above all  it is subsequently determined that the 2-methyl group on the indole ring is not required for CB₁ binding, and as a result tends to increase affinity for CB₂ .

Consequently, the 2-desmethyl derivative of JWH-007, JWH-018, has slightly higher binding affinity for CB₁, with an optimum binding of 9.00 nM at CB₁ and also 2.94 nM at CB₂, and so, JWH-007 displayed optimum binding of 9.50 nM at CB₁ and also 2.94 nM at CB₂.

So, another compound  similarly named JHW-007 (not JWH) is a cocaine analog (the di-para-fluoro benztropine, being essentially a hybrid between benzatropine and also difluoropine; with fluorine groups in the former or being descarbmethoxy in the latter).

Therefore atypical dopamine reuptake inhibitor, but is distinct from and not the same as this JWH-007.

Pharmacological effects of New Psychoactive Substances

However some of the psychoactive effects through a handful of pharmacological mechanisms include

• As a result of interactions with opioid receptor and also inhibitory neurotransmitters;
• For instance activation of the cannabinoid receptor type 1 (CB1);
• Therefore action of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor to produce, for example, sedative, hypnotic and anxiolytic effects;
• However modulation of the levels and  also actions of the monoamine neurotransmitters dopamine, epinephrine and serotonin;
• Similarly action as an N-methyl-D-aspartate (NMDA) receptor antagonist;
• Hence action which mediate specific serotonin receptor activities.

Inconclusion this product is not suitable for human consumption nor  veterinary use.