JWH-007

$300.00$2,400.00

What is JWH-007?

JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. Buy JWH-007 Online.

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JWH-007 For Sale

What is JWH-007?

JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. Buy JWH-007 Online.

Product Description, Buy JWH-007 Online

Chemical Name JWH 007
Synonyms (2-Methyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone-d9
CAS Number 1651833-48-5
Molecular Formula C₂₅H₁₆D₉NO
Molecular Weight 364.53
Category So, Standards; Pharmaceutical/API Drug Impurities/Metabolites;
So,Applications Most importantly,Labelled version of JWH-007 (J211340) is a novel cannabinoid receptor agonist at both the CB1 and CB2 receptors. Synthetic Cannabinoids

 

Above all it is most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman

Nevertheless several years after the family was initially described with the discovery of the N-morpholinylethyl compounds pravadoline (WIN 48,098), JWH-200 (WIN 55,225) and so WIN 55,212-2 by the Sterling Winthrop group.

In other words several other N-alkyl substituents were found to be active by Huffman’s team including the n-butyl, n-hexyl, 2-heptyl, and also cyclohexylethyl groups,

Above all  it is subsequently determined that the 2-methyl group on the indole ring is not required for CB1 binding, and as a result tends to increase affinity for CB2 .

Consequently, the 2-desmethyl derivative of JWH-007, JWH-018, has slightly higher binding affinity for CB1, with an optimum binding of 9.00 nM at CB1 and also 2.94 nM at CB2, and so, JWH-007 displayed optimum binding of 9.50 nM at CB1 and also 2.94 nM at CB2.

So, another compound  similarly named JHW-007 (not JWH) is a cocaine analog (the di-para-fluoro benztropine, being essentially a hybrid between benzatropine and also difluoropine; with fluorine groups in the former or being descarbmethoxy in the latter).

Therefore atypical dopamine reuptake inhibitor, but is distinct from and not the same as this JWH-007.

Pharmacological effects of New Psychoactive Substances

However some of the psychoactive effects through a handful of pharmacological mechanisms include

  • As a result of interactions with opioid receptor and also inhibitory neurotransmitters;
  • For instance activation of the cannabinoid receptor type 1 (CB1);
  • Therefore action of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor to produce, for example, sedative, hypnotic and anxiolytic effects;
  • However modulation of the levels and  also actions of the monoamine neurotransmitters dopamine, epinephrine and serotonin;
  • Similarly action as an N-methyl-D-aspartate (NMDA) receptor antagonist;
  • Hence action which mediate specific serotonin receptor activities.

Inconclusion this product is not suitable for human consumption nor  veterinary use.

 

Additional information

JWH-007

20g $ 300, 50g $600, 100g $ 800, 250g $1200, 500g $1800, 1kg $ 2400

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