Best Quality JWH-051 Available
What is JWH-051?
JWH-051 is an analgesic compound which is a cannabinoid agonist with it chemical structure is closely similar to that of the potent cannabinoid agonist HU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring. JWH-051 for sale
However it retains high affinity for the CB1 receptor, but is a much stronger agonist for CB2, with a Ki value of 14nM at CB2 vs 19nM at CB1.
It is one of the first CB2-selective ligands developed, although its selectivity for CB2 is modest compared to newer compounds such as HU-308.
It also have similar effects to other cannabinoid agonists such as sedation and analgesia, but with a relatively strong anti-inflammatory effect due to its strong activity at CB2.
Product Information,JWH-051 for sale
WH-015 was still effective in eliciting its anti-inflammatory effects despite the absence of CB2, suggesting the role of non-canonical.
Computational studies using molecular docking and molecular dynamics simulations showed that JWH-105 favorably binds to glucocorticoid receptor (GR).
Furthermore, knockdown of GR using siRNA abrogated JWH-015’s ability to reduce IL-1β-induced IL-6 and IL-8 production. In vivo, administration of JWH-015 (5 mg/kg, daily i.p. for 7 days at the onset of arthritis) significantly ameliorated AIA in rats.
Pain assessment studies using von Frey method showed a marked antinociception in AIA rats treated with JWH-015.
In addition, JWH-015 treatment inhibited bone destruction as evident from micro-CT scanning and bone analysis on the harvested joints.
Overall, our findings suggest that CB2 agonist JWH-015 elicits anti-inflammatory effects partly through GR.
This compound could be test as an adjunct therapy for the management of pain and tissue destruction as a non-opioid for RA.
However, pain management therapies are some of the most needed and demanded. A recent survey of 1,004 RA patients in the U.S.