Description

Top Quality JWH-210 for Sale

What is JWH-210?

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with Kᵢ values of 0.46 nM at CB₁ and 0.69 nM at CB₂. Buy JWH-210 in UK.

Effect of JWH-210, Buy JWH-210 in UK

Some of it adverse effects ınclude Tachycardia, nausea, somnolence, hypokalemia, hypertension, restlessness, and/or agitation were most frequently encounter.

Diplopia, seizures, syncope, and ECG changes such as T-wave inversion and bradycardia were also observe .

Acute adverse effects of JWH-210 typically include central nervous system depression or cerebral seizures, but also signs of sympathomimetic toxicity.

However Nausea  in 80% and typically shows a sudden onset shortly after inhalation, suggesting a central nervous effect possibly mediated by CB₁ receptors.

Cardiovascular effects are reported in up to 80% of the patients and might not only include alterations in blood pressure and heart rate,

but also changes in the electrocardiogram (ECG). JWH-210 as a representative of a strong CB₁ receptor agonist confirms previous reports about adverse effects of SC, but shows a distinct quantitative pattern of symptoms, compared to several other SC.

JWH-210 reduced expression levels of cytokines, such as interleukin-3, interleukin-5, and interleukin-6. Furthermore, we demonstrated that a CB2 receptor antagonist, AM630
inhibited JWH-210-induced cytotoxicity, whereas a CB1 receptor antagonist, rimonabant did not in primary cultured  splenocytes.

These results suggest that JWH-210 has a cytotoxicity via CB2 receptor action and results in decrement of lymphoid organ weights, T-cell activator, and cytokine mRNA expression levels.
A monohydroxy analog of JWH-210, a synthetic cannabinoid found in blends of the herbal mixture Spice or K2.

A major urinary metabolite of JWH-210, this biomarker is also refer to as the omega-1 hydroxy metabolite of JWH-210.

A monohydroxy analog of JWH-210, a synthetic cannabinoid found in blends of the herbal mixture Spice or K2. A major urinary metabolite of JWH-210, this biomarker is also referred to as the omega-1 hydroxy metabolite of JWH-210.