Best RCS-4 for Sale
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What is RCS-4 ?
About Binding of RCS-4, Best RCS-4 for Sale
RCS-4 [(4-methoxyphenyl)-1-yl-(1-pentyl-1H-indol-3-yl)methanone] represents the first of several N-alkyl-3-(methoxybenzoyl)indoles identified by forensic scientists as synthetic cannabinoid. Despite the detection of RCS-4 and several analogues (RCS-2, RCS-3, RCS-2-C4, RCS-3-C4, and RCS-4-C4) in products
The above are not intended for human consumption, relatively little is known about this class of cannabinoids.
The synthesis of all regioisomers of RCS-4 and their C4 homologues is describe.
Also systematically explored the structure-activity relationships of this class of SCs at human CB1 and CB2 receptors using an in vitro fluorometric imaging plate reader membrane potential assay. All compounds demonstrated agonist activity at CB1 (EC50 = 54-574 nM) and CB2 (EC50 = 4.5-46 nM) receptors, with the C4 homologues showing a preference for CB2 receptors over CB1 receptors (31-42 times).
Since most of the analogues (RCS-2, RCS-3, RCS-2-C4, RCS-3-C4 and RCS-4-C4) are not subject to regulation in much of the world, despite their activities towards CB1 and CB2 receptors, there is a possibility that these analogues will emerge on the market.
In August 2011, New Zealand added not only RCS-4 but also its 1-butyl homologue, and the 2-methoxybenzoyl isomers of both these compounds.
Risks to individual and society
It is a cannabinoid compound and so similar risks can occur. It could be use as a
substitute for cannabis.
However in general, adverse effects of SCRA intoxications are more intense than with cannabis, possibly because of their high activity and ease of overdosing.
Magnitude of the problem in countries.
RCS‐4 has been encounter as adulterants in herbal products that are smoke for their
However, the extent of the use of these products is largely unknown.
They also provide some evidence for clandestine manufacturing, diversion etc. Four respondents reports withdrawal,
Also tolerance and other adverse effects or medical illnesses, similar to other synthetic
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