Best Quality Pure UR-144
What is UR-144?
UR-144 is a selective full agonist of the peripheral cannabinoid receptor CB2, but with much lower affinity for the psychoactive CB1 receptor. Pure UR-144 for Sale.
Pharmacology, Pure UR-144 for Sale
Above all UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki of 150 nM.
As a result UR-144 was found to possess an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors.
UR-144 produces bradycardia and hypothermia in rats at a dose of 10 mg/kg, suggesting weak cannabinoid-like activity.
It is closely similar to other 2,2,3,3-tetramethylcyclopropyl synthetic cannabinoids which differ on the substitution of 1-position of the indole core.
In these compounds its 1-pentyl group is replace with alkylheterocycles like 1-(2 morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).
Therefore UR-144 is a synthetic cannabinoid of the tetramethylcyclopropyl series. Along with XLR-11, cyclopropyl Spice analogs have seen wide popularity in the illicit markets since late 2012. UR-144 was originally develop as a pharmaceutical drug candidate due to its high affinity for the cannabinoid receptor CB2.
However UR-144 is an analytical reference material categorize as a synthetic cannabinoid.1 It has been present in Spice/K2-type herbal blends.
UR-144 is regulate as a Schedule I compound in the United States. This product is intend for research and forensic applications.
A forensic standard of UR-144 is available, and the compound has been post on the Forendex website of potential compound of abuse .
An ELISA immunoassay technique for detecting UR-144 in urine as part of general compound screens is develop by Tulip Biolabs,
An Homogeneous Immunoassay that runs on most Clinical Chemistry Analyzers and detects several UR and XLR synthetic cannabinoids.