It is sale by many research chemical vendors as a legal alternative to the popular JWH-018, which had been banned in 2009.
Chemistry, Buy Pure THJ-018 Online
THJ-018, or 1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone, is a synthetic cannabinoid containing a substituted indazole structure.
THJ-018 is substitute at R1 with a pentyl chain. Additionally, the indazole core is substitute at R3 with a carbonyl group which is also binds to a napthalene moeity.
Napthalene is a bicyclic structure of two fused benzene rings.
This carbonyl bridge of THJ-018 classifies it as a ketone. THJ-018 is an analog of JWH-018 in which the core indole structure is substitute with an indazole base.
Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
Although this substance has not been formally studied, from analysis of the structure,
it is presume that THJ-018 has a similar binding profile to that of JWH-018 and matches many of the in vivo properties of Δ9-THC.
As with JWH-018, THJ-018 exhibits its range of effects via full agonism of both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.
THJ-018 is around 5x the potency of Δ9-THC. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.
The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of contributors.
As a result, they should be regard with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner,
although higher doses are more liable to induce the full spectrum of effects.
Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.