JWH-250

$250.00$2,400.00

What is JWH-250 ?

JWH-250 is a synthetic cannabinoid receptor agonist that has been detected in products since the late 2000s. Buy JWH-250 Online .

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Description

What is JWH-250 ?

JWH-250 is a synthetic cannabinoid receptor agonist that has been detected in products since the late 2000s. Buy JWH-250 Online .

Therefore it  is a phenylacetylindole and also  it works as an agonist at CB1 and CB2 receptors. It has an affinity of ~11 nM at CB1 and ~33 nM at CB2.

Product Description

Catalogue Number J211520
Chemical Name JWH-250 5-Hydroxypentyl
Synonyms 1-[1-(5-Hydroxypentyl)-1H-indol-3-yl]-2-(2-methoxyphenyl)-ethanone
CAS Number 1427325-83-4
Molecular Formula C₂₂H₂₅NO₃
Molecular Weight 351.44
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites; JWH Compounds/ and also Synthetic Cannabinoids;
Applications JWH-250 5-Hydroxypentyl is a urinary metabolite of JWH-250 (J211500) which also acts as cannabinoid receptor 2 agonist.

 

So, JWH-250 (K2/Spice) Synthetic Cannabinoid ELISA assay kit. 

The Tulip Biolabs JWH-250 (K2/Spice) Synthetic Cannabinoid ELISA Assay Kit is a 96-well microplate assay designed to  test the presence of JWH-250 and its metabolites in samples such as urine, whole blood, serum, and also plasma. Buy JWH-250 Online
Similarly using the positive control compound so JWH-250 N-4-hydroxypentyl metabolite standards, the limit of detection in urine is 5ng/mL.

So, Effects of JWH-250 , Buy JWH-250 Online

Therefore JWH-018 exhibits a traditional tach phylactic response in repeated dosing, with a notable decrease in both effect and duration after 3 days of chronic dosing .
In order words JWH-250 can likely produce this same effect. However this tolerance is likely the result of CB1/2 receptor downregulation, similar to the tolerance developed from ∆-9-THC.
However JWH-250 has been described as slightly more potent, however  though shorter lasting than JWH-018.
Similarly the Ki (binding affinity) values for primary cannabinoid (CB1/CB2) receptors are Ki = 11 and 33 nM, respectively, showing a greater selectivity for the CB1 receptor over the CB2 receptor. and also the Ki ratio for the receptors is thus CB1:CB2, 0.33.
Above all JWH-250 was discovered by, and so named after the researcher John W. Huffman. As a result  he created JWH-250 and also a number of other compounds to research the structure and above all  function of the endocannabinoid system of mammals.
 Therefore this compound does not have a naphthalene ring and so instead occupying this position with a 2′-methoxy-phenylacetyl group and also making JWH-250 a representative member of a new class of cannabinoid ligands

Additional information

JWH-250

10 g $ 250, 20 g $ 450, 50 g $ 670, 100g $ 960, 250g $ 1200, 500g $ 1700, 1kg $ 2400

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