What is JWH-250 ?
JWH-250 is a synthetic cannabinoid receptor agonist that has been detected in products since the late 2000s. JWH-250 for sale Australia .
Therefore it is a phenylacetylindole and also it works as an agonist at CB1 and CB2 receptors. It has an affinity of ~11 nM at CB1 and ~33 nM at CB2.
||Standards; Pharmaceutical/API Drug Impurities/Metabolites; JWH Compounds/ and also Synthetic Cannabinoids;
||JWH-250 5-Hydroxypentyl is a urinary metabolite of JWH-250 (J211500) which also acts as cannabinoid receptor 2 agonist.
So, JWH-250 (K2/Spice) Synthetic Cannabinoid ELISA assay kit.
The Tulip Biolabs JWH-250 (K2/Spice) Synthetic Cannabinoid ELISA Assay Kit is
a 96-well microplate assay designed to test the presence of JWH-250 and its metabolites in samples such as urine, whole blood, serum, and also plasma. Buy JWH-250 Online
Similarly using the positive control compound so JWH-250 N-4-hydroxypentyl metabolite standards, the limit of detection in urine is 5ng/mL.
So, Effects of JWH-250 , JWH-250 for sale Australia
Therefore JWH-018 exhibits a traditional tach phylactic response in repeated dosing, with a notable decrease in both effect and duration after 3 days of chronic dosing .
In order words JWH-250 can likely produce this same effect. However this tolerance is likely the result of CB1/2 receptor downregulation, similar to the tolerance developed from ∆-9-THC.
However JWH-250 has been described as slightly more potent, however though shorter lasting than JWH-018.
Similarly the Ki (binding affinity) values for primary cannabinoid (CB1/CB2) receptors are Ki = 11 and 33 nM, respectively, showing a greater selectivity for the CB1 receptor over the CB2 receptor. and also the Ki ratio for the receptors is thus CB1:CB2, 0.33.
Above all JWH-250 was discovered by, and so named after the researcher John W. Huffman. As a result he created JWH-250 and also a number of other compounds to research the structure and above all function of the endocannabinoid system of mammals.
Therefore this compound does not have a naphthalene ring and so instead occupying this position with a 2′-methoxy-phenylacetyl group and also making JWH-250 a representative member of a new class of cannabinoid ligands