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What is STS-135 ?

STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. Buy STS-135 Online UK

Chemistry, Buy STS-135 Online UK

Product Name: STS-135
Other Name : N-(adamantan-1-yl)-1-(5-fluropentyl)-H-indole-3-carbaxamide, 5-fluoro-APICA, 5FAPICA, 5F-2NE1
Formula: C24H31FN2O
Molecular Weight: 382.5

Metabolism

There is only one study evaluating in vitro STS-135 metabolism from human
hepatocytes (1); no clinical studies document human STS-135 in vivo. Detected metabolites includemono-, di-, or trihydroxylated metabolites, with and also without ketone formation, dealkylation,
However oxidative defluorination of N-fluoropentyl sidechain with possible oxidation to carboxylic acid;
Most hydroxylation and also ketone formation occur on the adamantane ring, and less commonly on the Npentyl side chain .

Therefore some metabolites can be further metabolize to glucuronides. Primary metabolites
included the monohydroxy STS-135 and the dihydroxy STS-135, both hydroxylated on the
adamantane system.

Effects and Toxicity

STS-135 is typically smoke or vaporize according to research study, typical doses are approximately 1 mg in humans as it is not possible to ensure purity or identity of the compound being smoke.

So, in herbal products, STS-135 concentrations were 49±2 and 47±4 mg/g from two packages of
commercial product (purchased at the same time), which also contained AM-2201, MAM-2201, andUR-144, XLR-11 (3).
There are no case reports documenting the effects of STS-135, nor are there any reports documenting cannabinoid receptor binding affinity.

Product Overview

In order words STS-135 is a designer compound purport  to be present in herbal blends. This compound features the fluoropentylindole structure of AM2201, a synthetic cannabinoid (CB), as well as an adamantyl carboxamide group, which may increase affinity for the peripheral CB2 receptor.

The physiological and toxicological properties of STS-135 are not known. This product is intended for research and forensic applications.

The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.

Above all  STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144.  STS-135 produces bradycardia and also hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity.