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What is 5F-PB-22?

5F-PB-22  also call  5F-QUPIC is a synthetic cannabinoid and agonist of the cannabinoid receptors which produces predominantly sedating subjective effects somewhat similar to that of cannabis. Buy 5F-PB-22 Online.

Product Details, Buy 5F-PB-22 Online

5-fluoro PB-22 3-carboxyindole is a metabolite of 5F-PB-22 a synthetic cannabinoid that binds to the cannabinoid CB1 and CB2 receptors.

However Synthetic cannabinoids interact with the same brain receptors as THC  and demonstrate to produce similar effects.

The compound  is typically spray on botanical material and smoke, although it can be ingest in liquid or powder form.

Products containing this compound  are  under a wide variety of names including (but not limited to) Spice, Potpourri, Smoke, K2, Zombie, Kush, and Cloud 10.

Effects

Above all 5F-PB-22 is an ester-type synthetic cannabinoid that acts as a full agonist at cannabinoid receptors CB1 and CB2 (EC₅₀ = 2.8 nM and 11 nM, respectively). Activation of the receptors results in Gi/o-dependent functional inhibition of adenylate cyclase, leading to reduced intracellular cAMP levels.

In vitro, 5F-PB-22 showed toxicity in cardiac and neuronal cell lines.

In vivo responses on experimental mice models are in line with other synthetic cannabinoid receptor agonists and show suppression of locomotor activities as well as induction of hypothermia and bradycardia

Chemistry

5F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic indolecarboxylate as it contains a substituted core indole structure.

This indole core is share with other cannabinoid substances including PB-22, JWH-018, and also AM2201.

5F-PB-22 is an ether with formula R-O-R’, is  a substance with two sub-units joined through an oxygen bridge.

The indole group of 5F-PB-22 is replace at R₅ with a fluoropentyl chain, a substitution share with 5F-AKB48.

Additionally, the indole core is also replace  at R₃ with a carboxylic acid group.

The terminal oxygen of this carboxylic acid is bond through an ether bond to a quinoline group at location R₈ of the heterocycle.